In the field of veterinary medicine, flufenicol occupies a pivotal position and can be called the star ingredient in the field of veterinary medicine. It is a broad spectrum antibiotic of chloramphenicol for animals, and it is also the most advanced and sensitive variety of chloramphenicol at present, with a chemical name of [specific chemical name], which is white or white crystalline powder, odorless but bitter.
Unlike some other antimicrobial drugs, flufenicol has a unique drug background that is strictly separated from humans and animals, which is particularly in line with the requirements of The Times for veterinary drugs when many veterinary products are shared by humans and animals. Its antibacterial spectrum is very wide, and it has a good inhibitory effect on gram-positive and gram-negative bacteria, and also has a strong antibacterial effect on anaerobic gram-positive bacteria and negative spirochaeta, Rickettsia, amoeba, etc. In practical applications, whether it is common Escherichia coli, Salmonella, or mycoplasma, chlamydia, etc., flufenicol can play a significant antibacterial effect, effectively inhibit the growth and reproduction of these pathogens, and escort animal health.
Second, the unique advantages of 30% flufenicol oral liquid.
(1) Efficient antibacterial, direct attack on the pathogen
The antibacterial effect of 30% flufenicol oral liquid is very strong, which can produce significant inhibition and killing effect on gram-positive and Gram-negative bacteria. Pathogenic bacteria such as pneumococcus, Escherichia coli, Staphylococcus aureus, Salmonella, Hemophilus parasuis, etc., are difficult to escape under the action of 30% flufenicol oral solution. Its antibacterial principle is to inhibit the synthesis of bacterial proteins to play a role, specifically, flufenicol can be closely bound to the 50S subunit of the bacterial 70S ribosome, thereby reducing the activity of peptide acyltransferase, inhibit the extension of the peptide chain, and ultimately interfere with the synthesis of bacterial proteins, so that bacteria can not grow and reproduce normally, to achieve the purpose of antibacterial.
(2) Rapid absorption, lasting effect
From the pharmacokinetic point of view, 30% flufenicol oral solution has the characteristics of rapid oral absorption. After oral administration in animals, the drug can quickly enter the blood circulation and reach the effective blood concentration in a short time. Moreover, it is widely distributed in animals and can quickly reach various tissues and organs to fully play an antibacterial role. Its long half-life, high blood concentration and long maintenance time mean that after a drug is used, the drug can continue to play a role in the animal body, effectively reducing the number of drugs, which not only facilitates the operation of farmers, but also reduces the stress response of animals, providing more lasting protection for the health of animals.
(3) Wide application, multi-faceted protection
In the actual breeding production, the application range of 30% flufenicol oral liquid is extremely wide, and it can play an important role in the prevention and treatment of common diseases in livestock, poultry and other animals. For example, in the breeding of pigs, for swine asthma, infectious pleuropneumonia, swine pulmonary disease, atrophic rhinitis, streptococcal disease caused by breathing difficulties, temperature rise, cough, decreased feed intake and other symptoms, have a strong effect, on E. coli caused by piglet yellow and white dysentery, enteritis, blood dysentery, edema disease and so on can also play an effective prevention and control role. In poultry breeding, it can be used to prevent and treat cholera caused by E. coli, Salmonella, Pasteurella, chicken white dysentery, diarrhea, intractable diarrhea, as well as bacteria, mycoplasma and other chronic respiratory diseases, infectious rhinitis and other diseases, effectively alleviate the respiratory tract and intestinal problems of birds, improve the health level of birds and breeding efficiency.
Treatment of animals and diseases
30% flufenicol oral liquid is widely used in livestock and poultry breeding and can effectively treat many common diseases.
(1) Pig diseases
Respiratory diseases: Swine asthma is a chronic respiratory infectious disease caused by Mycoplasma suis pneumoniae. The main manifestations of infected pigs are cough and asthma, especially in the morning and evening, after driving or exercise, which seriously affects the growth rate and feed conversion rate of pigs. Infectious pleuropneumonia is a highly contagious infectious disease caused by actinobacillus pleuropneumoniae. The body temperature of infected pigs rises to more than 40℃, they have difficulty breathing, they are sitting in a dog position, and they discharge bloody foamy secretions from the nose and mouth. Swine lung disease is caused by Pasteurella multocida. The body temperature of the acute type of pig disease can reach 41-42 ℃. The throat is swollen, warm, hard, and breathing is difficult. The pig is sitting in a dog position, and the mouth and nose discharge white foam. The main manifestations of chronic disease were cough, dyspnea and persistent wasting. In the treatment of these respiratory diseases, 30% flufenicol oral liquid can accurately act on pathogens, inhibit their growth and reproduction, effectively relieve symptoms such as cough and asthma of pigs, reduce respiratory inflammation, and promote the recovery of sick pigs.
Intestinal diseases: Piglet yellow and white dysentery is a common intestinal infectious disease of piglet caused by pathogenic Escherichia coli. Piglet yellow dysentery occurs in piglets aged 1-3 days, manifested as sudden diarrhea, yellow or yellowish white loose stool, containing small pieces of curd, and the infected piglet is rapidly wasted, dehydrated, and eventually dies. Piglet white dysentery occurs in piglets 10-30 days of age, with gray white discharge, mushy feces as the main characteristics, stink, poor spirit, growth and development of sick pigs. Blood dysentery is usually caused by spirochaeta dysenteriae. The sick pig produces a black or red stool with blood, mucus, and dead tissue debris. The sick pig is depressed, has decreased appetite, and is emaciated. Edema disease is mainly caused by the toxins produced by certain serotypes of Escherichia coli, which is commonly seen in piglets 1-2 weeks after weaning. The eyelids, head, neck and other parts of the sick pigs are edema, ataxia, and hoarseness. Although the incidence is not high, the mortality rate is high. For these intestinal diseases, 30% flufenicol oral liquid can effectively kill pathogenic bacteria in the intestine, regulate the balance of intestinal flora, repair the damaged intestinal mucosa, so as to relieve diarrhea, blood dysentery and other symptoms, promote the recovery of health of piglets, improve the survival rate and growth performance of piglets.
(2) Poultry diseases
Respiratory diseases: Chronic respiratory diseases are usually caused by Mycoplasma gallinis, and the manifestations of infected chickens are cough, sneezing, runny nose, respiratory rales, growth retardation, and decreased egg production in laying hens. Infectious rhinitis is caused by Bacillus paracarinae, inflammation of the nasal passages and sinuses, runny nose, swelling of the face, sneezing, breathing difficulties in severe cases, and a significant decrease in egg production in laying hens. In the treatment of poultry respiratory diseases, 30% flufenicol oral liquid can quickly act on the site of respiratory infection, inhibit the growth of pathogens, reduce inflammation, eliminate cough, dyspnea and other symptoms, promote the recovery of poultry respiratory function, and ensure the healthy growth and production performance of birds.
Intestinal disease: Chick white dysentery is a common infectious disease caused by Salmonella white dysentery, mainly occurs in chicks, sick chicks weak spirit, afraid of cold clumping, loose feathers, discharge white paste feces, often paste around the anus, commonly known as "paste anal", high mortality. Cholera is caused by Pasteurella multocida. Acute infected birds have elevated body temperature, depression, loose feathers, severe diarrhea, yellowish-green or grayish-white loose feces, mucus from mouth and nose, comb and fleshy cyanosis, and high mortality. The symptoms of chronic disease were edema of flesh beard, joint swelling and claudication. Refractory diarrhea may be caused by a variety of pathogenic bacteria infection or improper feeding management, long-term diarrhea of sick birds, thin feces, abnormal color, seriously affect the growth of birds and egg production performance. 30% flufenicol oral liquid can effectively inhibit the growth of intestinal pathogens, reduce intestinal inflammation, improve intestinal digestion and absorption function, so as to alleviate the symptoms of diarrhea, enhance the resistance of birds, promote the rehabilitation of sick birds, and improve the efficiency of breeding.
Fourth, scientific use to ensure curative effect
(1) Precise selection and medicine for the "disease"
When using 30% flufenicol oral solution, precise selection is crucial. Different animal species and disease types have different needs for drug dosage forms. For example, in poultry breeding, due to the short digestive tract of chickens, the release of flufenicol premix is relatively slow, and it is often excreted after oral absorption, basically unable to play a role, so chicken flufenicol soluble powder is a better choice; For waterfowl diseases, due to the physiological characteristics of waterfowl and infection routes, the use of flufenicol injection can more effectively deliver drugs to the lesions and play a therapeutic role. Only according to the specific situation of the animal and the characteristics of the disease, choose the appropriate dosage form of flufenicol products, in order to ensure that the drug can accurately act on the diseased site and improve the therapeutic effect.
(2) Reasonable compatibility and synergies
For different diseases, reasonable drug compatibility can significantly improve the therapeutic effect. When acute systemic infection occurs in animals, flufenicol alone may not be able to fully control the disease. In this case, the combination of "flufenicol soluble powder + doxycycline hydrochloride soluble powder + acetaminophen injection" can play a synergistic role. Flufenicol has a strong antibacterial effect on gram-positive and gram-negative bacteria, while doxycycline hydrochloride has a good inhibitory effect on mycoplasma, chlamydia and other pathogens. Combined use of the two can expand the antibacterial spectrum and enhance the antibacterial effect. Acetaminophen injection has antipyretic and analgesic effect, can effectively relieve the fever, pain and other symptoms of animal infection, make animals more comfortable in the treatment process, help to improve the resistance of animals, and promote the improvement of the condition.
In the treatment of digestive tract diseases in livestock and poultry, the compatibility of "flufenicol soluble powder + colistin sulfate soluble powder + berberine" is effective. Colistin sulfate mainly has a strong killing effect on gram-negative bacteria such as E. coli, Salmonella, etc. When combined with flufenicol, it can cover more pathogens causing digestive tract diseases and enhance the antibacterial effect. Berberine has the effect of clearing heat and drying dampness, promoting qi and relieving pain, improving intestinal inflammatory environment, relieving diarrhea, abdominal pain and other symptoms, and synergistic effect with flufenicol and colistin sulfate to treat digestive tract diseases from the aspects of antibacterial and regulating intestinal function, and promote the recovery of intestinal health of livestock and poultry.
(3) Precautions, safe drug use
When using 30% flufenicol oral solution, special attention should be paid to the side effects and contraindications of the drug. Flufenicol may cause certain damage to the liver and kidney of animals, and long-term or excessive use may lead to abnormal liver and kidney function, so the dosage and time of medication should be strictly controlled during the process of medication to avoid irreversible damage to the liver and kidney and other important organs of animals. Some animals may have allergic reactions to flufenicol, manifested as rash, shortness of breath, listlessness and other symptoms, once the animal allergy signs are found, the drug should be stopped immediately, and the corresponding anti-allergy treatment measures should be taken.
Flufenicol also has immunosuppressive effects, and when used during animal vaccination, it may reduce the immune effectiveness of the vaccine, so the use of flufenicol should be avoided for five days before and after vaccination. In addition, it also has fetal toxicity, can penetrate the placental barrier, have a toxic effect on the fetus, so during pregnancy or lactation, you should be careful to use flufenicol, so as not to affect the normal development of the fetus or lead to abnormal growth and development of young animals.
In terms of drug contraindications, flufenicol should not be used in combination with some drugs. When it is used in combination with macrolides (such as tylomycin, erythromycin, etc.), lincomines (such as lincomycin) and diterpenoid semi-synthetic antibiotics - Tymycin (mycogenin), it has an antagonistic effect, because they have the same mechanism of action, and the latter antibiotics can replace or prevent flufenicol from binding to the 50S subunit of bacterial ribosomes, resulting in reduced efficacy. Flufenicol should not be combined with β-lactam (such as penicillins, cephalosporins) and fluoroquinolones (such as enrofloxacin, ofloxacin, etc.), because flufenicol is a fast-acting inhibitor of bacterial protein synthesis, and the latter is a fast-acting fungicide during the breeding period, under the action of flufenicol, bacterial protein synthesis is inhibited. Bacteria stop growing and multiplying, which will weaken the bactericidal effect of the latter. In the treatment of diseases requiring rapid bactericidal action, it is especially important to pay attention to the use of these drugs at the same time. Flufenicol should not be mixed with sodium sulfadiazine for intramuscularly injection, and should not be combined with alkaline drugs during oral or intramuscularly administration, otherwise it will be decomposed and ineffective, and should not be mixed with tetracycline hydrochloride, kanamycin, adenosine triphosphate, coenzyme A, etc., to avoid precipitation and reduced efficacy.
When using 30% flufenicol oral liquid, farmers must strictly follow the scientific method and dosage, pay close attention to the reaction of animals, follow the drug contraindications, to ensure that the drug is safe and effective, and provide a strong guarantee for the healthy breeding of livestock and poultry.
Five, the choice of trust, quality assurance
Our company always regards product quality as the lifeline, in the production process of 30% flufenicol oral liquid, strictly follow the veterinary medicine production quality management practice (GMP), from raw material procurement to finished products, every link has been strictly tested and verified to ensure stable and reliable product quality. Our products are made of high quality flufenicol raw materials, through advanced production technology and strict quality control, to ensure the active ingredient content and stability of the drug, to provide a solid guarantee for animal health.
The actual use cases of many farmers have also fully proved the excellent quality and good efficacy of our 30% flufenicol oral liquid. A large pig farmer, his farm has an outbreak of pig asthma, many pigs appear cough, asthma symptoms, growth rate slowed down significantly. After using our 30% flufenicol oral solution, the disease was quickly controlled according to the scientific medication regimen. After only one course of treatment, the symptoms of most sick pigs were significantly reduced, the number of coughs and wheezes decreased, and the mental state and appetite gradually returned to normal. After a period of observation, the growth rate of the pig herd also returned to a normal level, and customers were full of praise for our products.
Another chicken farmer has seen her flock suffer from infectious rhinitis, with runny noses, swollen faces, sneezing and other symptoms, and egg production has plummeted. After treatment with our 30% flufenicol oral solution, the condition of the chickens was effectively relieved. The symptoms of runny nose and sneezing decreased significantly, the swelling of the face gradually subsided, and egg production gradually increased. The customer said that this product not only has a good therapeutic effect, but also is convenient to use, which greatly improves her farming efficiency, and will continue to choose our products in the future.
The true feedback from these customers is a powerful testimony to the quality and efficacy of our products. We will, as always, adhere to the principle of quality first, constantly improve product quality and service level, provide farmers with better quality and more efficient veterinary medicine products, and help the healthy development of livestock and poultry industry.
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